Yazar "Ersöz, Melike" için listeleme
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The antioxidant effect of boric acid in chronic alcohol abuse
Söğüt, İbrahim; Ersöz, Melike; Paltun, Sıla Özlem; Savaşan Söğüt, Melis; Hürdağ, Canan (Federation of European Biochemical Societies, 2015)Alcohol is a toxin that causes serious damage on many organs depending on the dose and duration of use. Chronic alcohol consumption is the most important factor that leads to cirrhosis and liver failure. In this study, ... -
Association of endothelial nitric oxide synthase promoter region (T-786C) gene polymorphism with acute coronary syndrome and coronary heart disease
Çiftçi, Çavlan; Melil, Süreyya; Çebi, Yurdanur; Ersöz, Melike; Kılıçgedik, M; Süsleyici Duman, Belgin; Çağatay, Penbe (BioMed Central, 2008)Background Nitric oxide (NO) is an endothelium derived relaxing factor (EDRF) which has an important role for regulating the heart-vessel physiology. The objective of this study was to evaluate the effects of the eNOS ... -
Borik Asitin 8305C Anaplastik Tiroit Kanseri Hücrelerinde Antioksidan ve Anti-kanser Aktivitesi
Ersöz, Melike (2021)Bu çalışmanın amacı, borik asitin 8305C insan anaplastik tiroit kanseri (ATK) hücrelerinde sitotoksik, anti-proliferatif, apoptotik ve antioksidan etkilerini değerlendirmektir. Borik asitin sitotoksisitesi 0-1000 ?g/mL doz ... -
C6 glioma hücrelerinde epigallokateşingallat ve resveratrolün biyokimyasal etkilerinin incelenmesi
Sarı, Pınar; Ersöz, Melike; Uslu, Ezel; Altuğ, Tuncay (Türk Biyokimya Derneği, 2012)Glioblastoma multiforme (GBM) nörolojik fonksiyon kaybına ve ölüme yol açan bir kanserdir. C6 glioma hücreleri malign glioblastoma özelliklerine sahip, GBM’nin araştırılmasında kullanılan bir soydur. -
Common variants in the ATP-binding cassette transporter 1 gene with decreased HDL-cholesterol levels and coronary artery disease.
Çatakoğlu, Alp Burak; Süsleyici-Duman, Belgin; Kurtoğlu, Hilal; Ersöz, Melike; Şener, Murat; Çelebi, Hüseyin; Aytekin, Saide (Elsevier, 2008)Background: Our aim was to determine whether the common variants within the coding sequence of ABCA1 gene affects low plasma high-density lipoprotein cholesterol (HDL-C) levels in Turkish patients with coronary artery ... -
Cytotoxic, anti-proliferative and anti-microbial activities of extract from cladonia pocillum
Coşkun, Zeynep Mine; Ersöz, Melike; Açıkgöz, Birkan; Karaltı, İskender; Çobanoğlu, Gülşah; Sesal, Cenk (2014)Lichens produce a wide variety of seconder metabolites which have a potential use as anti-microbial, cytotoxic, fungitoxic, anti-feedant, anti-oxidant, anti-inflammatory [1-3]. Many studies report that, the efficacy of ... -
The Effects of Camellia sinensis Extract on Proliferation, Apoptosis and Oxidative Stress in Insulinoma INS-1 Cells
Objective: Green tea (Camellia sinensis) is one of the most consumed beverages in the world. C. sinensis consumption may prevent tumor and other diseases. Insulinomas are pancreatic islet cell tumors. In present study, the ... -
Estradiol induces JNK-dependent apoptosis in glioblastoma cells
Altıok, Nedret; Ersöz, Melike; Koyutürk, Meral (Spandidos Publications, 2011)Estrogens exert multiple regulatory actions on cellular events in a variety of tissues including the brain. In the present study, the signaling mechanisms of the concentration-dependent effects of 17-β-estradiol (estradiol) ... -
Investigation of toxicity of various nanoparticles on cord originated mesenchymal stem cells
Ersöz, Melike; Allahverdiyev, Adil (Türk Moleküler Tıp Derneği, 2015)OBJECTIVE: Some of the commonly used stem cell components are bone marrow, adipose tissue, cord blood and cord matrix. Isolated cord derived using various methods (cord matrix ) high proliferation potential of mesenchymal ... -
Lack of association between endothelial nitric oxide synthase glu298Asp variation, visceral obesity and insulin related phenotypes in Turkish type 2 diabetic patients.
Bayoğlu, Burcu; Ersöz, Melike; Çağatay, Penbe; Çiftçi, Çavlan; Süsleyici-Duman, Belgin (Academy of Sciences and Arts of Bosnia and Herzegovina, 2008)Nitric oxide (NO) is an endothelium derived relaxing factor(EDRF) important in regulating heart-vessel physiology. Theobjective of this study was to investigate whether the eNOSgene Glu298Asp variation influenced the lipid ... -
Melatonin's effect on inflammatory cytokines in oxidative stress induced PC12 cells
Yapışlar, Hande; Özdaş, Şule; Akın, Demet; Ersöz, Melike (Wiley Online Library, 2013)Introduction: Melatonin is primarily synthesized and secreted by the pineal gland. Melatonin participate in many physiological and biochemical functions. The etiology of neurodegenerative diseases has not been well understood. -
Screening of anti-oxidative effects in Camellia sinensis L. leaves treated with boric acid
İsmailoğlu, Işıl; Coşkun, Zeynep Mine; Ersöz, Melike; Turan, Murat Ali (Society of Cell Membranes and Free Oxygen Radicals, 2014)Camellia sinensis L. (tea) is one of the most widely consumed drink in the World. The anti-oxidant role of boric acid has been reported. The present study was aimed to evaluate the alteration of anti-oxidative effects of ... -
Screening of antimicrobial activity and cytotoxic effects of two Cladonia species.
Açıkgöz, Birkan; Karaltı, İskender; Ersöz, Melike; Coşkun, Zeynep Mine; Çobanoğlu, Gülşah; Sesal, Cenk (De Gruyter, 2013)The present study explores the antimicrobial activity and cytotoxic effects in culture assays of two fruticose soil lichens, Cladonia rangiformis Hoffm. and Cladonia convoluta (Lamkey) Cout., to contribute to possible ... -
Simvastatin induces apoptosis in human breast cancer cells: p53 and estrogen receptor independent pathway requiring signalling through JNK
Koyutürk, Meral; Ersöz, Melike; Altıok, Nedret (Elsevier, 2007)The effect of simvastatin, a widely used statin for the treatment of hypercholesterolemia, was investigated in the estrogen receptor (ER)-positive MCF-7, and the ER-negative MDA-MB 231 human breast cancer cell lines. ...